300OB
Posted on 29 December 2025
The 300OB cohort comprised 302 individuals between 55 and 82 years old with a body mass index (BMI) above 27 kg/m2.
Recruitment was conducted at Radboud University Medical Center from 2014 to 2016. Blood samples were collected in the morning after an overnight fasting.
In this cohort, the available data are as follows:
- – Demographics and health-related information
- – Lipidomics and metabolomics
- – Magnetic resonance imaging of fat tissue and its distribution
- – Vascular measurements
- – Cytokine production upon incubation with various viral, fungal and bacterial stimuli
- – Circulating mediators (AAT, hsCRP, IL-6, IL-18, leptin, resistin, adiponectin etc.)
The 300OB study was approved by the CMO Regio Arnhem-Nijmegen (NL.46846.091.13).
Selected Publications
Menaker, Y., van den Munckhof, I., Scarpa, A., Placek, K., Brandes-Leibovitz, R., Glantzspiegel, Y., Joosten, L. A. B., Rutten, J. H. W., Netea, M. G., Gat-Viks, I., & Riksen, N. P. (2024). Stratification of Atherosclerosis based on Plasma Metabolic States. The Journal of clinical endocrinology and metabolism, 109(5), 1250–1262. https://doi.org/10.1210/clinem/dgad672
Tercan, H., Cossins, B. C., van Deuren, R. C., Rutten, J. H. W., Joosten, L. A. B., Netea, M. G., Hoischen, A., Bekkering, S., & Riksen, N. P. (2024). Association Between Clonal Hematopoiesis Driver Mutations, Immune Cell Function, and the Vasculometabolic Complications of Obesity. Journal of the American Heart Association, 13(2), e031665. https://doi.org/10.1161/JAHA.123.031665
Cossins, B. C., van den Munckhof, I., Rutten, J. H. W., van der Graaf, M., Stienstra, R., Joosten, L. A. B., Netea, M. G., Li, Y., & Riksen, N. P. (2023). Sex-specific Association Between Adipose Tissue Inflammation and Vascular and Metabolic Complications of Obesity. The Journal of clinical endocrinology and metabolism, 108(10), 2537–2549. https://doi.org/10.1210/clinem/dgad193
Brand, T., van den Munckhof, I. C. L., van der Graaf, M., Schraa, K., Dekker, H. M., Joosten, L. A. B., Netea, M. G., Riksen, N. P., de Graaf, J., & Rutten, J. H. W. (2021). Superficial vs Deep Subcutaneous Adipose Tissue: Sex-Specific Associations With Hepatic Steatosis and Metabolic Traits. The Journal of clinical endocrinology and metabolism, 106(10), e3881–e3889. https://doi.org/10.1210/clinem/dgab426
van der Heijden, C. D. C. C., Ter Horst, R., van den Munckhof, I. C. L., Schraa, K., de Graaf, J., Joosten, L. A. B., Danser, A. H. J., Netea, M. G., Deinum, J., Rutten, J., & Riksen, N. P. (2020). Vasculometabolic and Inflammatory Effects of Aldosterone in Obesity. The Journal of clinical endocrinology and metabolism, 105(8), 2719–2731. https://doi.org/10.1210/clinem/dgaa356
Ter Horst, R., van den Munckhof, I. C. L., Schraa, K., Aguirre-Gamboa, R., Jaeger, M., Smeekens, S. P., Brand, T., Lemmers, H., Dijkstra, H., Galesloot, T. E., de Graaf, J., Xavier, R. J., Li, Y., Joosten, L. A. B., Rutten, J. H. W., Netea, M. G., & Riksen, N. P. (2020). Sex-Specific Regulation of Inflammation and Metabolic Syndrome in Obesity. Arteriosclerosis, thrombosis, and vascular biology, 40(7), 1787–1800. https://doi.org/10.1161/ATVBAHA.120.314508