200FG

The cohort comprises 197 healthy adults working as foresters from the ‘Geldersch Landschap’, ‘Hoge Veluwe’, ‘Twickel’, and ‘Kroondomein het Loo’ in the Netherlands. These individuals were between 23 and 73 years old, and 77% were male, and 23% female.

Foresters were asked to donate blood to determine the serology against Borrelia bacteria, as Lyme disease occurs as an occupational disease. The cohort of individuals was chosen because of the good health reported by this general population. None of the volunteers included in the study had Borrelia infection. In this cohort, all individuals gave written informed consent to donate extra blood to use for research. Blood samples are collected annually.

Within this cohort;

• – Cytokine production upon incubation with various viral, fungal and bacterial stimuli
• – SNP genotyping
• – Transcriptome

measurements are available.

*The study was approved by the Ethical Committee of Radboud University Nijmegen (nr. 42561.091.12).

Selected Publications

Li, Y., Oosting, M., Deelen, P., Ricaño-Ponce, I., Smeekens, S., Jaeger, M., Matzaraki, V., Swertz, M. A., Xavier, R. J., Franke, L., Wijmenga, C., Joosten, L. A., Kumar, V., & Netea, M. G. (2016). Inter-individual variability and genetic influences on cytokine responses to bacteria and fungi. Nature medicine, 22(8), 952–960. https://doi.org/10.1038/nm.4139

Matzaraki, V., Beno, A., Jaeger, M., Gresnigt, M. S., Keur, N., Boahen, C., Cunha, C., Gonçalves, S. M., Leite, L., Lacerda, J. F., Campos, A., Jr, van de Veerdonk, F. L., Joosten, L., Netea, M. G., Carvalho, A., & Kumar, V. (2022). Genetic determinants of fungi-induced ROS production are associated with the risk of invasive pulmonary aspergillosis. Redox biology, 55, 102391. https://doi.org/10.1016/j.redox.2022.102391