The FUSE study recruited 192 healthy adults (33-52 years old) and 167 adults with severe infection (38-75 years old).

All participants were of Eastern European ancestry and enrolled between May 2017 and November 2019. Patients with sepsis, diagnosed according to Sepsis-2 criteria, were recruited at the Hospital for Infectious Diseases and Pneumology “Victor Babeş” Craiova, Romania. Healthy adult controls were recruited at the Human Genomics Laboratory, University of Medicine and Pharmacy of Craiova. Healthy individuals had no relevant medical history and were not taking any prescribed or self-administered medication.

In this cohort, the available data are as follows:

• – Demographics
• – Proteomics
• – Transcriptomics

*The study protocol was approved by the Ethics Committee of Academic and Scientific Deontology from the University of Medicine and Pharmacy of Craiova under the number 80/17.11.2016 and by the Ethics Committee of “Victor Babeş” Clinical Hospital of Infectious Diseases and Pneumology.

Selected Publications

Brandes-Leibovitz, R., Riza, A., Yankovitz, G., Pirvu, A., Dorobantu, S., Dragos, A., Streata, I., Ricaño-Ponce, I., de Nooijer, A., Dumitrescu, F., Antonakos, N., Antoniadou, E., Dimopoulos, G., Koutsodimitropoulos, I., Kontopoulou, T., Markopoulou, D., Aimoniotou, E., Komnos, A., Dalekos, G. N., Ioana, M., … Netea, M. G. (2024). Sepsis pathogenesis and outcome are shaped by the balance between the transcriptional states of systemic inflammation and antimicrobial response. Cell reports. Medicine, 5(11), 101829. https://doi.org/10.1016/j.xcrm.2024.101829

Ricaño-Ponce, I., Riza, A. L., de Nooijer, A. H., Pirvu, A., Dorobantu, S., Dragos, A., Streata, I., Roskanovic, M., Grondman, I., Dumitrescu, F., Kumar, V., Netea, M. G., & Ioana, M. (2022). Characterization of sepsis inflammatory endotypes using circulatory proteins in patients with severe infection: a prospective cohort study. BMC infectious diseases, 22(1), 778. https://doi.org/10.1186/s12879-022-07761-0